Receptor Binding Domain Change D225G Confirmed in Ukraine

Mill Hill has released a series of sequences from patients in Ukraine.  Four of the samples had the receptor binding domain change D225G.  Three samples were from lung, one from a throat swab.

Samples with D255G are listed below

A/Lviv/N6/2009

A/Lviv/N2/2009

A/Ternopil/N11/2009

A/Ternopil/N10/2009

All HA samples also had a Ukraine specific marker that had been previously found in swine.

More detailed analysis to follow.

http://www.recombinomics.com/News/11180902/Ukraine_D225G_Confirmed.html

Ukraine Dead Increase to 328 – Still No Sequences

Recombinomics Commentary 19:17
November 17, 2009
1,457,564 Influenza/ARI

83,526 Hospitalized

328 Deaths

The above numbers are in the latest update from the Ukraine Health Department and include 13 more deaths.  Although the number of deaths has decline slightly from the prior two days, the increase in cases and hospitalizations suggest the decline in deaths may be temporary.  The largest increase in cases was again in Kiev (5522 to 109,676) and two other eastern oblast (see map) had daily increases of more than 4000 cases (Dnipropetrovsk and Denetsk).  The steady rise in deaths continues to increase concerns over an H1N1 genetic change leading to an increase in lung disease such as those described earlier.

WHO came out with a situation update which provided little specific information beyond earlier reports that the H1N1 did not have large changes.  However, the new update did indicate that WHO regional centers in London and Atlanta were still investigating isolates, suggesting there have been sequences changes that are not fully characterized.

Recently released swine H1N1 from other locations have included receptor binding domain changes at position 225 (D225E, D225N, D225G) as well as 226 (Q226R) raising concerns that similar changes in Ukraine cold lead to the high frequency of fatal lung infections (Q226R has been seen previously in human H5N1 as well as H3 isolates from swine, ducks, and seals).  The new update did not address receptor binding domain changes or other SNPs that could have significant effects on the pathogenicity of the virus.

Therefore, the release of sequences and comments on receptor binding domain changes would be useful.


http://www.recombinomics.com/News/11170902/Ukraine_328.html

More Cover-Ups in Ukraine: WHO Withholds Gene Sequences As Cases Double Again

After infected cases double again in the Ukraine plague approaching the
1 million mark, the World Health Organization (WHO) is holding back gene sequences which could provide evidence of the mutation or recombination of the H1N1 or novel virus.

The numbers of cases from the latest update from Ukraine total 910, 640 hospitalized and Influenza cases (including acute respiratory illess). A total of 135 people have die according to official statistics.

The number of cases in Ukraine continues to expand. The number of patients with H1N1 symptoms is now approaching 1 million. Cases have been increasing at almost 200,000 per day, so it is likely that tomorrow’s report will have over 1 million cases. This rapid spread increases concern that the 15 sequences at Mill Hill contain one or more of these small changes, which has led to a delay in the announcement of sequence results.

More detail on the sequences at Mill Hill is overdue. The rapid spread of H1N1 in Ukraine demands rapid sequence results. Continued delay will only raise speculations and concerns.

http://preventdisease.com/news/09/110709_more_cover-ups_ukraine_plague_cases_double.shtml

VACCINE OPPONENTS IN THE UKRAINE TO BE ARRESTED

 

Critics in the Ukraine of vaccines are to be prosecuted by the government under criminal laws, according to a report from Interfax Ukrainia Agency.

The report says the Ukrainian Health Minister Wasilij Kniazevicz has asked the country’s top prosecutor to open criminal proceeedings against those people who are opposed to the implementation of the mass flu vaccination campaign also with the toxic and untested swine flu jab, sparking fears that the authorities are about to carry out wave of arrests.

The government’s Chief Medical Officer Aleksander Bilovol said that the government is planning to implement a mass vaccination campaign with pregnant women an especial target.

In addition, the Health Ministry is considering extending quarantine areas in the Ukraine, which could lead to the isolation of large regions and the virtual imprisonment of populations.

It has been reported that a key Ukrainian civilian public health body has been dissolved and integrated into the army, raising fears of forced mass vaccinations by the military.

Key functions in the Ukrainian government appear to have been taken over by officials from WHO and the UN under the pretext of fighting a pandemic emergency.

Many thanks to Krzysztof Tarnawski and Mareck Podlecki from Grypa666 for the translation of the report from Interfax-Ukraina Agency.

http://www.theflucase.com/index.php?option=com_content&view=article&id=1607%3Avaccine-opponents-in-the-ukraine-to-be-arrested&catid=41%3Ahighlighted-news&Itemid=105&lang=en

 

Ukraine: Influenza or Pneumonic Plague? The situation is getting worse and worse

Ukrainian News Agency “Fraza” reported that, according to informed sources, “it has been confirmed 100 % Pneumonic Plague in Ukraine”.

The Agency asserts that “the head physician of the medical institutions has sent out an informal disposal – not to sow panic, to refute the information about the plague, and to speak only of swine influenza”.

It is also required to distribute masks at health facilities with 8 levels of protection and anti-plague protection costumes. There is also an informal order not to allow any visitors to see the patients.

According to the “Fraza” agency, “today in Ukraine pneumonic plague is going in parallel with swine flu. The plague has killed over 60 people, and about 14 from the flu.

Meanwhile, the press service of the Ministry of Health of Ukraine reported that there is only one death from “California” virus A/N1N1 in Ukraine.

“In Ukraine there are 22 cases recorded of the virus A/N1N1 disease and there is only one fatal consequence as a result. All other cases of death from influenza has only a speculative attitude to “California” virus,” press service reports.

The situation with the epidemic of influenza is a complex and unpredictable because of the propensity of influenza A/H1N1 virus to mutation, said First Deputy Minister of Health Mr. Lazoryshynets on Monday, November 2.

“The situation is complicated and unpredictable. We found a strain of this virus in our laboratory … This virus is dangerous because it can mutate, and we can get a very different kind of virus, which was in Latin America or in Mexico, now it is European “, – said Lazoryshynets at a press conference, the “Correspondent” magazine informs.

At a press conference Lazoryshynets also said that there are 22  officially confirmed cases of influenza A/H1N1 in Ukraine.

First Vice Prime Minister Oleksandr Turchinov previously stated that as of Monday morning, November 2, there are 64 registered deaths in Ukraine from flu and acute respiratory viral infections.

Meantime, according to official information the highest level of epidemiological risk is declared in Ivano-Frankivsk (Stanislav) area, from 2 November. This decision was made by Ivano-Frankivsk Regional emergency epidemiological commission at the extended session on November 2.

In accordance with the Commission, quarantine will last for all educational institutions in the area until 20 November, a commission to monitor the distribution of medicines is also made, which come in the region as humanitarian aid.

The commission agreed that health workers will provide individual first aid kit. There will be extra transport allocated to visit patients by the district doctors.

According to the Ministry of Health, today in Ukraine there are 255 000 registered cases of influenza and SARS, of whom 15 000 were hospitalized.

Ministry of Transport and Communications of Ukraine introduced a permanent monitoring of the situation on a clear implementation of the planned anti-epidemic measures in public transport.

A special monitoring group studied the transport department on November 2, how the anti-epidemiological measures were applied at the Kiev railway station, central bus station of the capital and the International airport “Borispol”.

Polish epidemiologists November 3 arrive in Ukraine for obtaining specimens from patients with the Ukrainians. The experts will arrive in Lviv, where it is supposed to take 190 samples.

Polish epidemiologists are expected to arrive in Ukraine on November 3 to obtain samples from patients. The experts will arrive in Lviv, where 190 samples are to be taken.

Lithuanian Foreign Ministry on November 2 recommended to the residents of Lithuania to refrain from unnecessary trips to the Ukraine.

Department of Monitoring,
Kavkaz Center

http://pimpinturtle.com/2009/11/05/ukraine-influenza-or-pneumonic-plague-the-situation-is-getting-worse-and-worse.aspx

Ukraine Hemorrhagic Pneumonia Deaths

Ivano-Frankivsk Oblast
All the six dead young people had symptoms of severe hemorrhagic pneumonia. The disease starts slowly, with temperature rising to 37.2 – 37.3 degrees, slight cough and pain in joints. Nasal catarrh developed at the end of the second or third day. Autopsy revealed that the lungs were soaked with blood, the oblast chief specialist said.
The above comments are from an early story describing cases in Ukraine. The clustering of hemorrhagic cases raised concerns. The concern was increased by anecdotal reports citing a high frequency of such cases in Lviv. The recent WHO announcement that they were initially focusing of severe acute respiratory illness in Lviv also increased concerns.
Hemorrhagic pneumonia was also observed in the 1918 pandemic and was thought to be linked to cytokine storm. Consequently, those with robust immune systems (previously health young adults) disproportionately died, which has also been seen in the current outbreak. However, the cases in Ukraine appear to be clustered, raising concerns that the virus has changed.
However, the change may be minor, since the current H1N1 has produced the above symptoms in current cases. More severe cases may be linked to a higher viral load, which could be linked to minor genetic changes, or simply due to concentration of virus in schools. In the US the spread of the virus has been linked to school openings, which lead to an explosion of cases and subsequent student deaths. However, now there are increases in fatalities in teachers and administrators, increasing concerns worldwide.
In Ukraine, weather changes and heating issues may have led to a surge in cases, and increased concentrations of virus could have produced conditions favoring high viral loads and increased cytokine storms.
Samples have been sent to Mill Hill, and sequence data should be released shortly. Similarly, investigations on hemorrhagic pneumonia in lviv should help resolve the mechanism for the high concentration of such cases in western Ukraine.
However, H1N1 spread in Kiev has been noted, and other countries such as Belarus have announced additional H1N1 suspect or confirmed fatalities. Sequence analysis of these cases and an update on the frequency of hemorrhagic pneumonia in Ukraine and worldwide would be useful
Henry L. Niman, Ph.D.
President, Founder
Recombinomics, Inc.
648 Field Club Road
Pittsburgh, PA 15238
412.963.1362 Office
617.877.0987 Cell
http://www.twitter.com/hniman
http://www.recombinomics.com

Spanish flu in Ukraine?

Via UrbanSurvival:

The BIG story this morning, economic in nature, is that “Swine Flu Grips Ukraine“.  It’s in the Wall Street Journal, after all, so it must have something to do with economics, right?

 

And indeed it does:  Ukraine is something of a bread basket area to Russia populated by smart, hard-working people.  Since independence in late summer 1991, Ukraine has been evolving into the 29th largest economy in the world on a mix of agriculture, aerospace, and manufacturing while being a critical chunk of real estate to the Russians since goods like natural gas from Russia to Europe through its borders.

 

As of this weekend, 53 people have died of swine flu, some by what’s described as bleeding lungs which hark back to the 1918 Spanish Flu and cytokine storming where the body’s defensive mechanisms got crazy and attack the host body itself.

 

Responding to the situation, the government is closing down schools, some businesses, banning large gatherings, and is trying to buy another 700,000 doses of Tamiflu from Roche.  A stock to watch?

 

The thing we probably should watch over the next few days is how the neighboring countries fare.  Already Hungary’s health minister says the “Ukraine flu epidemic to create emergency in Hungary” as it may also do in Romanian, Moldova, Slovakia, Poland, Belarus, Russia, and anyone pulling into port from he Black Sea or the Sea of Azov.

 

Now we go into deep background mode on this with an email I received from a particularly well informed reader who expects this will be one for the history books that should be watched closely:

“This story may be the most important of our lifetimes. I’m a retired Ph.D. biochemist FYI. I conjecture that much of the coming troubles the web bot project speaks of may well arise from this new flu variant. I note that the first cases appeared a few days ago, just the length of the incubation period from October 25th.

OK, a Mossad microbiologist warned two months ago that a new deadly flu bug was going to be released into Ukraine in two months. He got the place right, the bug right, and the time right.

The sequence of all 8 pieces of RNA in the virus that caused the “Spanish flu” pandemic of 1918-1919 is public knowledge. A long dead Inuit woman buried in the permafrost was dug up and the virus taken from her body a couple of years ago and the RNA pieces were sequenced. Quite simple to synthesize these 8 pieces with widely available commercial machines and reagents. Then transfect mammalian cells with the RNA genes to obtain the intact, fully functional, virus. Another quite well known technology. Then grow all you want in fertilized chicken eggs or a mammalian immortal cell line. More quite well known technologies.

What scares the sh*t out of me is that the bleeding in the lungs is exactly what killed a lot of folks in the 1918-19 pandemic. See the great book “The Great Influenza: The story of the deadliest pandemic in history .” People would literally fall dead walking across the street. The bleeding out of the lungs was most likely the result of a “cytokine storm” that so increased the vascular permeability in the air sacks that blood filled the lungs. The reason why the mortality in the 1918-1919 pandemic was concentrated in the 18-25 yo cohort was that they had the most active immune systems.

Now I’ve NO conjecture as to who may have let this loose or why. But I do know that the technology is widespread to replicate the 1918-1919 virus that killed 2-4 million Americans and about 50 million world wide. And folks only traveled by ship in 1918. And there is NO vaccine for this flu type.

Hopefully we will know in a couple of weeks the sequences of the 8 RNA pieces in the Ukraine virus. I’ll bet the farm that it is a replicant of the “Spanish Flu.” If so, the odds are totally infinitesimal that this was NOT a deliberate bioweapon release.

I note that long haul truckers will simply go home and park their rigs if this flu reaches the USA. And exactly what reason do we have to suppose that it will be confined to Ukraine? The average city has 3 days of food. Connect the dots… please……………

A credit is due here. the word “replicant” is from the great sci-fi movie “Blade Runner.”

All of this is puts us on the scale of impact somewhere in the middle between inconvenient to bad on one end of the scale to horrific and Biblical at the far end.  But the linguistics seem to be pointing to the most terrible of all yet to come with temporal hints around the time of the Whistler Olympics (late February to mid March) for another round of dispersal.

 

The nonzero probabilities keep adding up and at some point, even the most skeptical human has to reach the point of non-coincidence and conclude what’s for now only a possibility:  Namely that the factions of the PowersThatBe are at war with one-another and we – humans down here at the worker bee level – are the unwilling cannon fodder for the coming year or longer.

http://urbansurvival.com/week.htm